AMD Instinct MI355X VS AMD Instinct MI300X

Choosing between **Instinct MI355X** and **Instinct MI300X** depends on your specific AI workload requirements. The **Instinct MI355X** leads in both memory capacity and raw compute power, making it a stronger choice for high-end LLM training. Currently, you can rent these GPUs starting from **$2.29/h** and **$0.95/h** respectively across 8 providers.

AMD

Instinct MI355X

VRAM 288GB
FP32 210 TFLOPS
TDP 1000W
From $2.29/h 2 providers
AMD

Instinct MI300X

VRAM 192GB
FP32 163.4 TFLOPS
TDP 750W
From $0.95/h 6 providers

📊 Detailed Specifications Comparison

Specification Instinct MI355X Instinct MI300X Difference
Architecture & Design
Architecture CDNA 4 CDNA 3 -
Process Node 3nm 5nm + 6nm -
Target Market datacenter datacenter -
Form Factor OAM OAM -
Memory & Bandwidth
VRAM Capacity 288GB 192GB +50%
Memory Type HBM3e HBM3 -
Memory Bandwidth 8.0 TB/s 5.3 TB/s +51%
Memory Bus Width 8192-bit 8192-bit -
Compute Infrastructure
Stream Processors 24,576 19,456 +26%
AI & Compute Performance (TFLOPS)
FP32 (Single Precision) 210 TFLOPS 163.4 TFLOPS +29%
FP16 (Half Precision) N/A 1,307.4 TFLOPS
FP64 (Double Precision) N/A 81.7 TFLOPS
INT8 (Integer Precision) N/A 2,614.9 TOPS
Power & Efficiency
TDP (Thermal Design Power) 1000W 750W +33%
PCIe Interface PCIe 5.0 x16 PCIe 5.0 x16 -

🎯 Use Case Recommendations

🧠

LLM & Large Model Training

AMD Instinct MI300X

Higher VRAM capacity and memory bandwidth are critical for training large language models. The Instinct MI355X offers 288GB compared to 192GB.

AI Inference

AMD Instinct MI300X

For inference workloads, performance per watt matters most. Consider the balance between FP16/INT8 throughput and power consumption.

💰

Budget-Conscious Choice

AMD Instinct MI300X

Based on current cloud pricing, the Instinct MI300X starts at a lower hourly rate.

Automated Comparison

Technical Deep Dive: Instinct MI355X vs Instinct MI300X

This is a generational comparison within the AMD ecosystem, pitting CDNA 4 against CDNA 3. The Instinct MI355X has a significant **96GB VRAM advantage**, which is crucial for training massive datasets or large language models. From a cost perspective, the **Instinct MI300X** is currently about **59% cheaper** per hour, offering better value for budget-conscious projects.

AMD Instinct MI355X is Best For:

  • Massive LLM training
  • Budget projects

AMD Instinct MI300X is Best For:

  • LLM inference at scale
  • Large VRAM capacity
  • CUDA-only software

Frequently Asked Questions

Which GPU is better for AI training: Instinct MI355X or Instinct MI300X?

For AI training, the key factors are VRAM size, memory bandwidth, and tensor core performance. The Instinct MI355X offers 288GB of HBM3e memory with 8.0 TB/s bandwidth, while the Instinct MI300X provides 192GB of HBM3 with 5.3 TB/s bandwidth. For larger models, the Instinct MI355X's higher VRAM capacity gives it an advantage.

What is the price difference between Instinct MI355X and Instinct MI300X in the cloud?

Cloud GPU rental prices vary by provider and region. Based on our data, Instinct MI355X starts at $2.29/hour while Instinct MI300X starts at $0.95/hour. This represents a 141% price difference.

Can I use Instinct MI300X instead of Instinct MI355X for my workload?

It depends on your specific requirements. If your model fits within 192GB of VRAM and you don't need the additional throughput of the Instinct MI355X, the Instinct MI300X can be a cost-effective alternative. However, for workloads requiring maximum memory capacity or multi-GPU scaling, the Instinct MI355X's architecture may be essential.

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