NVIDIA A40 VS AMD Instinct MI250

Choosing between **A40** and **Instinct MI250** depends on your specific AI workload requirements. The **Instinct MI250** leads in both memory capacity and raw compute power, making it a stronger choice for high-end LLM training. Currently, you can rent these GPUs starting from **$0.08/h** and **$1.30/h** respectively across 11 providers.

NVIDIA

A40

VRAM 48GB
FP32 37.4 TFLOPS
TDP 300W
From $0.08/h 10 providers
AMD

Instinct MI250

VRAM 128GB
FP32 45.3 TFLOPS
TDP 500W
From $1.30/h 1 providers

📊 Detailed Specifications Comparison

Specification A40 Instinct MI250 Difference
Architecture & Design
Architecture Ampere CDNA 2 -
Process Node 8nm 6nm -
Target Market datacenter datacenter -
Form Factor Dual-slot PCIe OAM -
Memory & Bandwidth
VRAM Capacity 48GB 128GB -63%
Memory Type GDDR6 HBM2e -
Memory Bandwidth 696 GB/s 3.2 TB/s -78%
Memory Bus Width 384-bit 8192-bit -
Compute Infrastructure
CUDA Cores 10,752 N/A
Tensor Cores (AI) 336 N/A
RT Cores (Ray Tracing) 84 N/A
Stream Processors N/A 13,312
AI & Compute Performance (TFLOPS)
FP32 (Single Precision) 37.4 TFLOPS 45.3 TFLOPS -17%
FP64 (Double Precision) N/A 45.3 TFLOPS
Power & Efficiency
TDP (Thermal Design Power) 300W 500W -40%
PCIe Interface PCIe 4.0 x16 PCIe 4.0 x16 -

🎯 Use Case Recommendations

🧠

LLM & Large Model Training

AMD Instinct MI250

Higher VRAM capacity and memory bandwidth are critical for training large language models. The Instinct MI250 offers 128GB compared to 48GB.

AI Inference

NVIDIA A40

For inference workloads, performance per watt matters most. Consider the balance between FP16/INT8 throughput and power consumption.

💰

Budget-Conscious Choice

NVIDIA A40

Based on current cloud pricing, the A40 starts at a lower hourly rate.

Automated Comparison

Technical Deep Dive: A40 vs Instinct MI250

This head-to-head pits NVIDIA's Ampere against AMD's CDNA 2. The Instinct MI250 has a significant **80GB VRAM advantage**, which is crucial for training massive datasets or large language models. From a cost perspective, the **A40** is currently about **94% cheaper** per hour, offering better value for budget-conscious projects.

NVIDIA A40 is Best For:

  • Visual computing
  • AI inference
  • HPC

AMD Instinct MI250 is Best For:

  • HPC
  • Matrix math workloads
  • CUDA native apps

Frequently Asked Questions

Which GPU is better for AI training: A40 or Instinct MI250?

For AI training, the key factors are VRAM size, memory bandwidth, and tensor core performance. The A40 offers 48GB of GDDR6 memory with 696 GB/s bandwidth, while the Instinct MI250 provides 128GB of HBM2e with 3.2 TB/s bandwidth. For larger models, the Instinct MI250's higher VRAM capacity gives it an advantage.

What is the price difference between A40 and Instinct MI250 in the cloud?

Cloud GPU rental prices vary by provider and region. Based on our data, A40 starts at $0.08/hour while Instinct MI250 starts at $1.30/hour. This represents a 94% price difference.

Can I use Instinct MI250 instead of A40 for my workload?

It depends on your specific requirements. If your model fits within 128GB of VRAM and you don't need the additional throughput of the A40, the Instinct MI250 can be a cost-effective alternative. However, for workloads requiring maximum memory capacity or multi-GPU scaling, the A40's architecture may be essential.

Ready to rent a GPU?

Compare live pricing across 50+ cloud providers and find the best deal.