NVIDIA GB200 NVL72 VS AMD Instinct MI300X

Choosing between **GB200** and **Instinct MI300X** depends on your specific AI workload requirements. The **GB200** leads in both memory capacity and raw compute power, making it a stronger choice for high-end LLM training. Currently, you can rent these GPUs starting from **$10.50/h** and **$0.95/h** respectively across 9 providers.

NVIDIA

GB200

VRAM 384GB
FP32 180 TFLOPS
TDP 1200W
From $10.50/h 3 providers
AMD

Instinct MI300X

VRAM 192GB
FP32 163.4 TFLOPS
TDP 750W
From $0.95/h 6 providers

📊 Detailed Specifications Comparison

Specification GB200 Instinct MI300X Difference
Architecture & Design
Architecture Blackwell CDNA 3 -
Process Node 4nm 5nm + 6nm -
Target Market datacenter datacenter -
Form Factor Rack-scale OAM -
Memory & Bandwidth
VRAM Capacity 384GB 192GB +100%
Memory Type HBM3e HBM3 -
Memory Bandwidth 16.0 TB/s 5.3 TB/s +202%
Memory Bus Width 8192-bit 8192-bit -
Compute Infrastructure
CUDA Cores 36,864 N/A
Stream Processors N/A 19,456
AI & Compute Performance (TFLOPS)
FP32 (Single Precision) 180 TFLOPS 163.4 TFLOPS +10%
FP16 (Half Precision) 9,000 TFLOPS 1,307.4 TFLOPS +588%
FP64 (Double Precision) N/A 81.7 TFLOPS
INT8 (Integer Precision) 18,000 TOPS 2,614.9 TOPS +588%
Power & Efficiency
TDP (Thermal Design Power) 1200W 750W +60%
PCIe Interface PCIe 5.0 x16 PCIe 5.0 x16 -

🎯 Use Case Recommendations

🧠

LLM & Large Model Training

NVIDIA GB200 NVL72

Higher VRAM capacity and memory bandwidth are critical for training large language models. The GB200 offers 384GB compared to 192GB.

AI Inference

NVIDIA GB200 NVL72

For inference workloads, performance per watt matters most. Consider the balance between FP16/INT8 throughput and power consumption.

💰

Budget-Conscious Choice

AMD Instinct MI300X

Based on current cloud pricing, the Instinct MI300X starts at a lower hourly rate.

Automated Comparison

Technical Deep Dive: GB200 vs Instinct MI300X

This head-to-head pits NVIDIA's Blackwell against AMD's CDNA 3. The GB200 has a significant **192GB VRAM advantage**, which is crucial for training massive datasets or large language models. From a cost perspective, the **Instinct MI300X** is currently about **91% cheaper** per hour, offering better value for budget-conscious projects.

NVIDIA GB200 NVL72 is Best For:

  • Massive LLM training
  • Trillion-parameter models
  • Single-node tasks

AMD Instinct MI300X is Best For:

  • LLM inference at scale
  • Large VRAM capacity
  • CUDA-only software

Frequently Asked Questions

Which GPU is better for AI training: GB200 or Instinct MI300X?

For AI training, the key factors are VRAM size, memory bandwidth, and tensor core performance. The GB200 offers 384GB of HBM3e memory with 16.0 TB/s bandwidth, while the Instinct MI300X provides 192GB of HBM3 with 5.3 TB/s bandwidth. For larger models, the GB200's higher VRAM capacity gives it an advantage.

What is the price difference between GB200 and Instinct MI300X in the cloud?

Cloud GPU rental prices vary by provider and region. Based on our data, GB200 starts at $10.50/hour while Instinct MI300X starts at $0.95/hour. This represents a 1005% price difference.

Can I use Instinct MI300X instead of GB200 for my workload?

It depends on your specific requirements. If your model fits within 192GB of VRAM and you don't need the additional throughput of the GB200, the Instinct MI300X can be a cost-effective alternative. However, for workloads requiring maximum memory capacity or multi-GPU scaling, the GB200's architecture may be essential.

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