NVIDIA Tesla P100 VS AMD Instinct MI250

Choosing between **P100** and **Instinct MI250** depends on your specific AI workload requirements. The **Instinct MI250** leads in both memory capacity and raw compute power, making it a stronger choice for high-end LLM training. Currently, you can rent these GPUs starting from **$0.08/h** and **$1.30/h** respectively across 7 providers.

NVIDIA

P100

VRAM 16GB
FP32 9.3 TFLOPS
TDP 300W
From $0.08/h 6 providers
AMD

Instinct MI250

VRAM 128GB
FP32 45.3 TFLOPS
TDP 500W
From $1.30/h 1 providers

📊 Detailed Specifications Comparison

Specification P100 Instinct MI250 Difference
Architecture & Design
Architecture Pascal CDNA 2 -
Process Node 16nm 6nm -
Target Market datacenter datacenter -
Form Factor Dual-slot PCIe OAM -
Memory & Bandwidth
VRAM Capacity 16GB 128GB -88%
Memory Type HBM2 HBM2e -
Memory Bandwidth 732 GB/s 3.2 TB/s -77%
Memory Bus Width 4096-bit 8192-bit -
Compute Infrastructure
CUDA Cores 3,584 N/A
Stream Processors N/A 13,312
AI & Compute Performance (TFLOPS)
FP32 (Single Precision) 9.3 TFLOPS 45.3 TFLOPS -79%
FP64 (Double Precision) N/A 45.3 TFLOPS
Power & Efficiency
TDP (Thermal Design Power) 300W 500W -40%
PCIe Interface PCIe 3.0 x16 PCIe 4.0 x16 -

🎯 Use Case Recommendations

🧠

LLM & Large Model Training

AMD Instinct MI250

Higher VRAM capacity and memory bandwidth are critical for training large language models. The Instinct MI250 offers 128GB compared to 16GB.

AI Inference

AMD Instinct MI250

For inference workloads, performance per watt matters most. Consider the balance between FP16/INT8 throughput and power consumption.

💰

Budget-Conscious Choice

NVIDIA Tesla P100

Based on current cloud pricing, the P100 starts at a lower hourly rate.

Automated Comparison

Technical Deep Dive: P100 vs Instinct MI250

This head-to-head pits NVIDIA's Pascal against AMD's CDNA 2. The Instinct MI250 has a significant **112GB VRAM advantage**, which is crucial for training massive datasets or large language models. From a cost perspective, the **P100** is currently about **94% cheaper** per hour, offering better value for budget-conscious projects.

NVIDIA Tesla P100 is Best For:

  • Legacy AI workloads
  • Precision-heavy training

AMD Instinct MI250 is Best For:

  • HPC
  • Matrix math workloads
  • CUDA native apps

Frequently Asked Questions

Which GPU is better for AI training: P100 or Instinct MI250?

For AI training, the key factors are VRAM size, memory bandwidth, and tensor core performance. The P100 offers 16GB of HBM2 memory with 732 GB/s bandwidth, while the Instinct MI250 provides 128GB of HBM2e with 3.2 TB/s bandwidth. For larger models, the Instinct MI250's higher VRAM capacity gives it an advantage.

What is the price difference between P100 and Instinct MI250 in the cloud?

Cloud GPU rental prices vary by provider and region. Based on our data, P100 starts at $0.08/hour while Instinct MI250 starts at $1.30/hour. This represents a 94% price difference.

Can I use Instinct MI250 instead of P100 for my workload?

It depends on your specific requirements. If your model fits within 128GB of VRAM and you don't need the additional throughput of the P100, the Instinct MI250 can be a cost-effective alternative. However, for workloads requiring maximum memory capacity or multi-GPU scaling, the P100's architecture may be essential.

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